However, with DSM-5, a single diagnosis, “Autism Spectrum Disorder”, has replaced the previous subtypes. These aforementioned disorders were separately defined in Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV). These disorders lie on a continuum of severity and diagnostic criteria overlap to a great extent. Autism, Asperger’s syndrome and Pervasive Developmental Disorder- Not Otherwise Specified (PDD-NOS) are neurodevelopmental disorders characterized by varying degrees of impairments in social interaction, communication and repetitive behaviors and interests. AIIMS-Modified-INDT-ASD Tool is a simple and structured instrument based on DSM-5 criteria which can facilitate diagnosis of ASD with acceptable diagnostic accuracy.Īutism spectrum disorders (ASDs) are neurodevelopmental disorders that are characterized by deficits in two core domains: (a) impairments in social interaction and communication and (b) restricted, repetitive behavior (RRB). A score ≥14 on the tool was suggestive of severe ASD (CARS>36.5) with a sensitivity and specificity of 80% and 80.7% respectively. The modified tool demonstrated sensitivity of 98.4% and specificity of 91.7% to diagnose ASD. Two-hundred-twenty-five children (159 boys, median age = 47months) were enrolled. In addition, receiver operating characteristic (ROC) curves were used to determine the cut-off for total score as compared to Childhood Autism Rating Scale (CARS) score to grade the severity of ASD. The modified tool was validated against DSM-5 diagnostic criteria. The modifications were done using Delphi method and included: (a) rearrangement of questions from the previous tool and (b) addition of new questions on sensory symptoms. This study was undertaken to develop and validate the DSM-5 based All India Institute of Medical Sciences (AIIMS)-Modified-INDT-ASD Tool. The introduction of DSM-5 necessitated revision of existing INDT-ASD tool to incorporate the DSM-5 related changes. Diagnostic and Statistical Manual of mental disorder-IV (DSM-IV) TR based INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD) is an established instrument for the diagnosis of ASD in Indian subcontinent and low-middle income countries (LMIC).
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